Yuen-Jong Liu, M.D.

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My research interests have evolved from pure mathematics (number theory at the Research Science Institute at MIT) to artificial intelligence (Open Mind Common Sense project at MIT Media Lab) to computational genomics (nucleosome pattern recognition in yeast genome microarrays at the Harvard Center for Genomics Research) to surgical outcomes (free flap outcomes and quantitative breast surgery in the Section of Plastic Surgery at Yale University). Each step represented a transition to a field with more immediate human applications while applying experience and skills accumulated during my education. Combining my experience in data analysis and pattern recognition with a thorough training in surgery, I would like to optimize patient outcomes in evidence-based surgery.

Specific Interests

Projects and Publications

I studied the aesthetics of breast shape under Dr. J. Grant Thomson in the Section of Plastic Surgery at Yale. I determined the relationship between breast volume, surface area, and anthropomorphic measurements that results in the most aesthetically pleasing shape, with the ultimate goal of optimizing patient satisfaction in cosmetic and reconstructive breast surgeries. I am first/second author in the following publications:

In addition, I worked with Dr. Thomson to correlate free flap survival with intra-operative patient temperatures, showing mild intra-operative hypothermia to be beneficial in free flap transfers. I am first author in the following publication:

I also studied the molecular history of pseudogenes in Mark Gerstein's lab in the Department of Molecular Biophysics and Biochemistry at Yale. I am first/co-author in the following publications:

During college, I worked in Steve Altschuler and Lani Wu's lab for three years when we were located at the Harvard Center for Genomics Research. I developed computational models to simulate gene networks and applied hidden Markov models to tiled genomic microarray data. I am second author in the following publication:

During college, I also worked in Marvin Minsky's lab at the MIT Media Labs on the Open Mind Common Sense Project, building data structures to represent common sense knowledge and enabling a computer to understand concepts that humans often take for granted.

In high school, I explored an unsolved problem in number theory at the Research Science Institute (RSI 1999) and analyzed gastrointestinal creatine absorption by infrared spectroscopy.


Other Publications